Research workspace · registry aware

Cancer Research Platform

A pipeline-guided workspace for molecular characterization, evidence exchange, and reproducible research reporting.

Cancer Discovery Pipeline

Seven-stage research framework

Data
Molecular state
Biomarkers
Vulnerabilities
Pharmacology
Validation
Report

Data & Methods

Declared sources, schemas, and validation gates.

Dataset references describe intended inputs. Planned registration does not imply that data has been downloaded, harmonized, or approved for analysis.

Dataset contracts

Inputs referenced by registered modules

Open dataset registry

planned

DEPMAP_CRISPR_GENE_EFFECT

Planned harmonized CRISPR gene-effect dataset; release and semantics are not yet locked.

Source: Cancer Dependency Map
Version: pending-source-lock
Layer: CURATED
Required by: P002

planned

GDC_TCGA_BRCA_CASE_METADATA

Planned immutable TCGA-BRCA case/sample metadata source snapshot required for deterministic research-cohort construction; no source snapshot is locked. Curated linkages receive a separate dataset identity.

Source: NCI Genomic Data Commons
Version: pending-source-lock
Layer: RAW
Required by: P001

planned

GDC_TCGA_BRCA_RNA

Planned immutable TCGA-BRCA STAR Counts source dataset; the GDC source release and file inventory are not yet locked. Curated expression receives a separate dataset identity.

Source: NCI Genomic Data Commons
Version: pending-source-lock
Layer: RAW
Required by: P001, P002

planned

GDC_TCGA_BRCA_SOMATIC_MUTATIONS

Planned immutable open TCGA-BRCA masked somatic mutation MAF source dataset; the GDC source release and file inventory are not yet locked. Curated mutation data receives a separate dataset identity.

Source: NCI Genomic Data Commons
Version: pending-source-lock
Layer: RAW
Required by: P001

planned

GDSC_DRUG_RESPONSE

Planned harmonized GDSC response dataset; licensed release and response semantics are unresolved.

Source: Genomics of Drug Sensitivity in Cancer
Version: pending-source-lock
Layer: CURATED
Required by: P002

planned

PDC_PROTEOMICS

Planned harmonized proteomics dataset; study, source release, and processing are unresolved.

Source: NCI Proteomic Data Commons
Version: pending-source-lock
Layer: CURATED
Required by: P002

planned

PRISM_DRUG_RESPONSE

Planned harmonized PRISM response dataset; release, dose, and viability semantics are unresolved.

Source: PRISM Repurposing
Version: pending-source-lock
Layer: CURATED
Required by: P002

Typed exchange

Artifact schema contracts

These types define potential evidence exchange; they are not published result records.

CandidateVulnerabilitySchema 1.0.0
DrugResponseEvidenceSchema 1.0.0
FunctionalDependencySchema 1.0.0
ProteinValidationEvidenceSchema 1.0.0

Validation lifecycle

Declared quality gates

Gate presence is a contract requirement, not proof that a gate has passed.

G0
Required validation checkpoint
G1
Required validation checkpoint
G2
Required validation checkpoint
G3
Required validation checkpoint
G4
Required validation checkpoint
G5
Required validation checkpoint
G6
Required validation checkpoint
G7
Required validation checkpoint