RAW
Immutable source files with acquisition metadata and checksums.
Shared dataset registry · Versioned provenance
Projects request declared dataset versions through one central registry, reducing redundant acquisition logic and protecting shared harmonized data from silent mutation.
Data boundaries
Every dataset belongs to an explicit layer with different mutability and reuse expectations.
Immutable source files with acquisition metadata and checksums.
Shared harmonized representations using canonical platform identifiers.
Hypothesis-specific derived data owned by a project release.
Generated catalog
These records describe contracts and provenance. This architecture scaffold does not download scientific source data.
DEPMAP_CRISPR_GENE_EFFECT
Planned harmonized CRISPR gene-effect dataset; release and semantics are not yet locked.
GDC_TCGA_BRCA_CASE_METADATA
Planned immutable TCGA-BRCA case/sample metadata source snapshot required for deterministic research-cohort construction; no source snapshot is locked. Curated linkages receive a separate dataset identity.
GDC_TCGA_BRCA_RNA
Planned immutable TCGA-BRCA STAR Counts source dataset; the GDC source release and file inventory are not yet locked. Curated expression receives a separate dataset identity.
GDC_TCGA_BRCA_SOMATIC_MUTATIONS
Planned immutable open TCGA-BRCA masked somatic mutation MAF source dataset; the GDC source release and file inventory are not yet locked. Curated mutation data receives a separate dataset identity.
GDSC_DRUG_RESPONSE
Planned harmonized GDSC response dataset; licensed release and response semantics are unresolved.
PDC_PROTEOMICS
Planned harmonized proteomics dataset; study, source release, and processing are unresolved.
PRISM_DRUG_RESPONSE
Planned harmonized PRISM response dataset; release, dose, and viability semantics are unresolved.
Data safety
This repository must not contain patient identifiers, protected sample-level data, secrets, credentials, or large source datasets.